Chapter 3 The Ambition of Chasu City

Someone said back then that Chinese and Western cultures eventually went their separate ways because the East produced porcelain and the West produced glass. After the glass has been ground, a container that can be quantified and a microscope that enters the onlookers appear. Of course, this is also a family talk.

However, the development of microscopes has given doctors a better understanding of gadgets.

"As we all know, the current mainstream opinion in the academic circles is that the structure of DNA is helical, but the real thing changes due to movement. After tuberculosis cells are killed by a series of isoniazid and rifampicin drugs, the bacterial DNA structure retained has changed. At this time, its results have changed.

From a stable helical structure to a more stable G4 structure, it is first a G-tetrad plane (G-tetrad) formed by hydrogen bonds between adjacent 4 G bases on the same DNA single strand. Such quadruplet planes appear repeatedly, forming a G-quadruplex (G-quadruplex). In the middle of the plane, there is usually also a cation (mostly a potassium ion) that helps stabilize the structure...."

When Zhang Fan said these words, the experts and scientists in the venue instantly turned the quiet venue into a buzzing mode, and some people in the venue raised their hands. Regarding Zhang Fan's new statement, everyone is not Doubt, but surprise, surprise that Zhang Fan can clearly state the changed structure now.

Zhang Fan nodded slightly, pointing to a beautiful female scholar who was obviously from the East.

Zhang Fan's so-called NDA structure change, how to describe it, probably means that a piece of paper is partially burnt but not completely carbonized. If it is completely carbonized, this is the so-called organic change, directly changing from paper to carbon. Medicines that can treat paper completely lose their potency.

Drug-resistant nodules are the intermediate product of paper and carbon. This product is the most troublesome. It is more stable than paper and less stable than carbon. The selectivity of drugs is a huge challenge for doctors. Maybe the medicine that was effective the day before became ineffective overnight.

"Dao Ke Te Zhang, is your so-called G4 structure a mimetic or actually found in tuberculosis bacteria?"

Zhang Fan originally thought that this girl was from the Hua country, but when he stood up and spoke, Zhang Fan felt that she was from the Wanzi country. This is bragging, if there is no Rendanhu on the lips and a small pillow on the back, Zhang Fan really can't tell the difference.

Hearing the woman's question, Zhang Fan hesitated for a moment, but still gave an affirmative reply: "In the tea element laboratory, we have observed this structure."

The woman quickly asked again: "Why haven't anyone from the tea lab published any papers on this topic?"

This shit,

I kindly ask you to stand up and ask a question, but you actually want to *, "This question is not part of today's report."

"Swordsman Special Zhang, can you simulate this structure?" Another white-haired beauty stood up and asked.

There is such a peculiar phenomenon in the medical field that among young experts, there are more female experts than male experts. Not only in Huaguo, but in other countries as well. Of course, if you insist on talking about a piece of cloth on your head, you won't be able to talk about it.

But after entering middle age or entering the top expert group, there are many more male experts than female experts.

The simplest ones, such as obstetrics and gynecology, in Jieqing Guoyou, etc., there are a lot of female doctors, but after entering the academician level, there are many more male academicians, and I don’t know why.

Zhang Fan nodded, "Yes!"

Then, Zhang Fan turned around, picked up a pen and began to write on the blackboard.

The first is the simulation state, which is the chemical structure of the so-called hydrogen-bonded carbon base. Zhang Fan explained while writing.

"You said that he was a surgeon, so why did he jump into the pit of tuberculosis? Look at his familiarity. At the beginning, some people said that he embezzled other people's scientific research results, and then the person concerned dared not stand under his guidance. Come out and talk.

Look at the current level of others, can this be drawn by a person who usurped other people's scientific research achievements? "

"It's too good, we have nowhere to go for the good ones." Although he said so, seeing the experts from all over the world as quiet as elementary school students in class, the Huaguo infectious disease experts who came together still felt a little bit Proud.

On this stage, the Hua people have been missing for too long, and now they finally have the voice of the Hua people.

Once Zhang Fan started writing on the blackboard, he completely entered a mode of talking to himself. There is a joke on the Internet, saying that the eyes of liberal arts students are like looking at a lover, and the eyes of science students are like looking at a fool.

Usually, Zhang Fan is not too obvious, but once he enters the serious mode, his eyes really look like fools when looking at others.

But as Zhang Fan wrote more and more, everyone began to enter a state of confusion. Why is there an extra hydrogen bond here? The G4 of the telomere helps to protect the DNA at the end of the chromosome, but it can also inhibit the activity of telomerase?

When the WHO officials saw it, they immediately contacted the leaders of the Huaguo Ministry, "Can this report be opened as a video conference, so that more experts in this field can come in and discuss it?"

"This is related to the knowledge protection of scholars in our country, and hasn't Golden Retriever always criticized our hygiene. I think we can let go of this bad accusation before it disappears completely, but we can't let Golden Retriever experts participate."

The leaders of the ministry finally got tough. Although they quarreled in the past, they couldn't check and balance the golden retriever. Moreover, they brought a group of younger brothers, and they really fought more with less.

It's all right now, if he doesn't seize this opportunity to fight back today, his leadership position can be regarded as a family heirloom.

"We support Hua Guo!"

"We also support Hua Guo!"

In the venue, a group of Gallic chickens first started to stand on the side of Huaguo. To be honest, they really want the tea medicine to enter their country cheaper. On the land of Africa, because of AIDS, One malaria and one tuberculosis killed more people than war.

Seeing the reserved look of the leaders of the Huaguo Ministry, the golden retriever and representatives of European countries gritted their teeth, "I withdraw my remarks against Huaguo on tuberculosis and apologize. Huaguo is a country with great responsibility.. ..."

When the leaders of the ministry heard that the golden retriever bowed his head, his nose became rosacea with joy, and the red one was very conspicuous. "Okay, after all, we are also a responsible big country. We can open up and have video conferences."

When the video was connected, it was mainly labs in developed countries that connected.

"Director, this model fits the structure and properties of drug-resistant tuberculosis."

"Their tuberculosis drug was designed based on this model, but where is the node? It seems that they are moving faster than us." In the golden retriever's laboratory, a group of people watched a person keep writing on the monitor. I'm drawing.

Not only golden retrievers, but all laboratories above the standard in developed countries in Europe and America are watching this meeting.

"The new structure of DNA, so can it be said that other bacteria or cells have similar structures?"

"This structure is not evolved, but can be said to be produced by chemical drugs. It is not naturally formed, but will this structure be produced in animal cells?"

The discussion was heated, and now no one questions the correctness of this model.

"I just don't know where their node is, their luck is too good."

After the tuberculosis drug was developed, after several rounds of research, no papers or academic reports were published in China.

Then, adhering to Huaguo's tradition of using one generation, developing one generation, and designing one generation, after the tea-su hospital's tuberculosis drugs have entered the third generation, Chasu Hospital applied to the country to start selling tuberculosis drugs abroad.

That's why today's report came about.

Of course, this report is just to tell you a principle. It probably means come and see, there is gold in the Sahara Desert. You see, I dug this gold in the Sahara Desert, but it was dug in the desert. , Sorry, this has nothing to do with today's report.

In the venue, I want to mention

After Zhang Fan finished writing, he quietly stood in front of the blackboard writing, "It's really beautiful, isn't it?"

A group of people didn't know whether Zhang Fan was talking about the beauty of his writing on the blackboard or the beautiful structure of nodules. But now this is the key, now everything Zhang Fan says is right.

"Tuberculosis drugs from China must be imported!"

"We must import tuberculosis drugs from Huaguo!"

"Find a way to import tuberculosis drugs from China!"

A report by Zhang Fan directly made the pharmaceutical factory in Chasu's high-tech zone smile crookedly. The previous clinical phase III did not meet European and American standards, and it did not meet the FDA of Golden Retrievers.

Now, they have compromised on Huaguo's tuberculosis drugs. Not only has it compromised, but they must also use the standard of tea, the drug standard of tea in the field of tuberculosis.

"It's so expensive? Twenty dollars for a box?"

Cha Su Hospital, Ouyang looked at the price list in surprise.

In Cha Su Hospital, among a series of research and development, the tuberculosis drug is the most expensive, but the most indebted is also the tuberculosis drug. After the drug was handed over to the state, let alone the subsidy behind the scenes, the subsidy on the surface was just to make the scientific research of Chasu Hospital pay back.

Originally, Ouyang thought it was just like this, as long as he didn't lose money, but now when he wakes up, the sky has changed!

"Except for a small part of free support to African countries, the prices of other countries are uniform."

Xiao Chen reported to Ouyang with a smile.

The Chasu government can wake up with a smile when they are asleep now, because they earn one dollar for each box of tuberculosis medicine.

"It's a good sign, it's a good sign, we must do a good job in service work, we must do a good job in security work, and we must seize the opportunity to let the Chasu Hospital produce a few more leading products. Next year, our Chasu City will hit the economic leader in the frontier. city!"

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