Six Hundred and Sixty-Five, the Egg Is Hatched, the Old Lady Is Hatched!

Volume 665 of the main text of Yilu Tantu has hatched, and my mother has hatched! A drug, here specifically refers to a compound drug, if it wants to enter the clinic, it can be the same as the old Tang's study, anyway, it can't be avoided after traveling through mountains and rivers.

The simplest, AIDS clinical trials have failed more than 200 times, and the money in it can almost be counted as the water of the Yellow River, flowing out. Others, such as herpes, were also unsuccessful.

Many drugs felt like seed players before the third period, but they entered the third period, and they were all deceitful silver-like pewter guns.

In layman's terms, the trials before the third phase were all literary dramas, but in the third phase of the clinical trial, this is the real work, whether it works or not, this thing will be shown at this time.

Around the world, more than 10,000 medicinal compounds are developed a year, and then about 200 to 300 can enter animal experiments, and no more than ten actually enter the third phase of clinical trials.

It can be said to be one in a million.

In the trials before the third phase, the tests were often qualitative, such as whether eating this thing would cause other diseases to appear. For example, the drug of tea, found a pair that can make mice live. This is one of them.

Seriously speaking, the study was to treat intestinal tumor suppressor drugs, and as a result, the skin of the mice peeled off. This is a failed chemical synthesis.

What is the third-phase trial? In a nutshell, the first-phase toxicology, pharmacokinetics, look at drug toxicity and metabolic mechanism; Window, to determine the dose of the drug, and initially measure the effectiveness and safety of the drug; phase III, large-scale effectiveness and safety trials, to verify that the drug can treat the disease and is safe to use.

After passing these three phases of trials, you can apply for NDA to the regulatory authorities. In fact, there are still four phases.

Therefore, the general drug instructions tell you to take according to the measurement, and you should take according to the measurement. Other than that, there is gold in it, but you must take a handful when you take the medicine. Life is big.

Drugs are toxic, especially for some drugs, the window of safe dosage is very narrow, and if there is more, it will turn from a cure to a murder poison.

Moreover, before the clinical trial, once the drug is qualified in the laboratory, a second appropriate animal experiment is required before the data can be used as the human experiment.

To put it more simply, this thing is to experiment with human cousins ​​who have not been out of the fifth server. Although the regulatory authorities of various countries do not specify a certain animal, they have a requirement: animal experiment data with pharmacological relevance.

This is so plainly stated, take the monkey as the knife!

Small-molecule drugs generally require test data from rodent species, and more stringent ones generally use slightly larger mammals, such as miniature pigs and dogs.

As for Zhao Yanfang and the others, they will use their cousins ​​who have not yet appeared in the fifth suit of humans, primates!

So, although I am happy now, the pressure is not small.

The current situation is actually that the Long March has just begun, and if it fails, it will die in the Jinsha River. The pressure is really not small, but there is hope now!

Therefore, Zhang Fan now tells himself in his heart that he must be steady, must be steady, and must not be swayed. If it really sloshes and falls, the boss of the tea government will probably cry.

All the way west, on the highway, Kuluze was speeding steadily, and the two ladies were catching up on sleep. Those who didn't know it thought that the two of them stole corn from others last night.

Zhang Fan listened to the love song of Xihai by the Phoenix Group, and ran all the way towards Chasu.

After passing the Tianshan Mountains, the scenery is immediately different.

If we say that the scenery here in Niaoshi is similar to that in Su Province, except that the land is a bit flatter, it is actually mainly earthy yellow.

On the bare mountain, like a child without hair, he tied up a chicken and sang an elephant.

But once you cross the Tianshan Mountains and enter the land of tea, the scenery is different. The highway runs through the Tianshan Mountains, and you can see the snow-capped mountains in the distance. Looking at the white snow in the summer, you can feel a little cooler in your heart. On both sides of the road are all kinds of fir trees, which are lush and straight into the sky.

Really, extremely beautiful.

After entering the Chasu Land, he obviously didn't arrive home, but Zhang Fan could clearly feel that he had arrived home.

After the two of them put down to catch up on sleep, Zhang Fan drove into the hospital.

...

The laboratory in the hospital was overcrowded. Lao Chen looked out while wiping the sweat from his brow, and when he saw Zhang Fan's car, he hurriedly said, "Yuan Zhang is here, Yard Zhang is here."

Except for Ouyang, the others were ready to welcome Zhang Fan.

Zhang Fan entered the laboratory and took a look, hey! The leaders in charge of sanitation from Chasu have all come, and rubbing their hands together, it is estimated that beads of sweat have been rubbed into pills.

"If you don't come today, I guess the doors here will be smashed." Ouyang looked at the group of people around him unwillingly.

"What about the report, I'll take a look at the report first."

Zhang Fan hurriedly asked.

"I've made the decision. Before you came, the report was sealed and no one can read it first." Ouyang said.

"Take it out quickly, Zhang Yuan is here!" The leader in charge of sanitation was quite dissatisfied with Ouyang, just like a junior high school student waiting for the owner of the video hall to show a movie in the middle of the night.

After a while, the report was brought over. Zhang Fan found an office, and opened it to take a look after entering.

Ouyang whispered to Zhang Fan: "The security of the laboratory is probably not good enough."

"It's not necessary, it's not yet in the third phase of clinical trials." Zhang Fan didn't understand.

"What do you know, something is going to happen, you have no place to cry. Look at how complicated people come and go in this place.

People from Maruko Country, Golden Retriever Country, moderation, numbers, and doctors from various places who came to experiment, some don’t, do you know what they think? "

When Ouyang said this, Zhang Fan felt that the old lady was right. Something is really going wrong, who can he find to cry.

"Okay, you are right, let the Chasu government come forward?"

"No, don't we have a good relationship with Lu Hang? They borrowed our plane last time. I mean let Lu Hang send a company over!"

"Eh!" Zhang Fanhan came down. Ouyang's tone is too strong. One company, one hundred people, you haven't done anything yet, you want a company, if you really can do something, don't all the frontier military regions have to move to Chasu Hospital!

"Okay, okay, okay, I'll let Lao Chen contact you later. Use as little as you can because of your face, and save it for the critical moment."

Zhang Fan comforted the old lady, and the old lady was very helpful!

Opening the report, Zhang Fan felt a bit pained. It was too hard for him to read this report, it was almost all in English, and there were a lot of chemical formulas.

The head is getting bigger!