Chapter 198 Luck

"Professor Yu, can't USTC also chemically synthesize coenzyme Q10 through solanesol?" Director Hai held the phone, his hands sweating.

The voice of the phone was a bit distorted, but he said clearly: "Our institute has no special research in this area, but as far as I know, there is no precedent for industrializing this technology in China. The Beijing Institute of Biological Products seems to have a similar project , you can inquire about it."

"I've called, and they've already given up on the project." Director Hai squeezed the phone tightly, feeling weird

Even the project that the Beijing Institute of Biological Products hadn’t done yet was actually made by Yang Rui. If it weren’t for the precedent of the WestJet factory, he would definitely have met a liar

But if it is not a liar, this technology is too powerful, no wonder Zeneca easily agreed to drop shares, and it does not require technology transfer like last time

It seems that they knew that the value of technology was too high, so they did not discuss the issue of technology transfer

Perhaps, it is hoped that after the factory is put into production, it will steal from it.

Director Hai was amused by his own thoughts, and then he felt proud again. Foreigners stole teachers from China. Domestic magazines and newspapers like to write such stories, but only those in the professional field know that the current China and Foreign countries, how big is the gap

A full 10 years of wastage has brought about not only ten years of backwardness, but also twenty or thirty years. Also in the field of biotechnology, China's technology is still at, or in other words, the peak of China's technology is still at synthetic insulin

However, synthetic insulin in the 1960s was no longer a rare thing in the 1980s, but in China, there are not many people who can replicate this experiment

Professor Yu said "Oh" on the other end of the phone as a matter of course, and said with a smile: "It's a pity to give up, and it's not surprising. In the past two years, too many projects have been cut, and coenzyme Q10 is not an important drug related to the national economy and people's livelihood.

"Then you said, if the University of Science and Technology of China or the Beijing Institute of Biological Products restarts the project, how long will it take to see the results?

"Our school will not do this project." Professor Yu's hearty voice came, and he said with a smile: "The current goal of our school is to track the latest international basic research, such as biological macromolecules, stem cells, gene functional groups, etc. etc. The production of coenzyme Q10 is of an applied nature, even if there is state funding, it may not be possible to spare manpower.

"How long do you think it will take to restart the project of the Beijing Institute of Biological Products?"

"It's hard to say."

"Professor Yu, we know each other so well, so you can analyze it so that I can know how to make a decision." Director Hai said softly. Although he is in charge of the sales of raw materials and refined chemicals across the country, his subordinates are Four departments, more than 20 people, none of them can do research. Whenever this kind of thing happens, he always asks a familiar professor to ask

Professor Yu is also willing to maintain a mutually beneficial relationship with Director Hai, pondered for a moment, and said: "I can't do analysis for others, so I just guess. If this technology is restarted, whether the research results can be achieved is actually a bit of luck.

"How to say?

"After 20 or 30 years of laboratory technology, why can't we do industrial transformation? There are many reasons, the main point is that the properties of coenzyme Q10 are quite special, and its intermediates are not stable enough, so laboratory technology cannot If it is directly used in the factory, the factory production is tantamount to opening up a new way to produce substance A through solanesol, and then transform it into substance B, C, D, and finally to coenzyme Q10, all of which must be stable Matter, do you think it’s easy or not?” Professor Yu sounded like teaching students

Director Hai listened very seriously.

Question: "I don't know much about technology, so I just want to ask, isn't it the same for other factory production technologies?

"Not all. Some laboratory technologies can be used directly in the factory, because the route it takes in the laboratory and the intermediate products it passes through are suitable for use in the factory. Let me use an analogy, chemical synthesis is like starting from From one place to another, the intermediate product is the bridge to pass through. There are four intermediate products, that is, there are four bridges. Laboratory technology is like walking. Bridges are fine, and the researchers don’t force them. When you encounter wooden bridges, you can use wooden bridges. If you need stone bridges, you can use stone bridges. You can also use pontoon bridges. Factory production is like trucks pulling goods, and its conditions are harsh. Well, at least it has to be a stone bridge, and if the scale of the factory is large, it has to be a railway bridge, do you understand?"

"That is to say, some laboratory technologies happen to encounter stone bridges and above, and coenzyme Q10 technologies are all wooden bridges and pontoon bridges?"

"That's what it means, but it's more than that. If you think about it, even if the first three bridges are all stone bridges, and the fourth bridge is not a stone bridge, you still can't pass, and you have to go back to the third, or the second bridge." The first bridge, or even the first bridge, starts again. If you still can’t find the way to the whole stone bridge, this synthesis scheme will never be used. The laboratory technology of semi-chemical synthesis of coenzyme Q10 has been around for a long time, which shows that many people have explored Passing by, it’s not working now, it means it’s very difficult, you want to know how long it will take to make it, I don’t think anyone can guarantee it.”

Director Hai thought about it, and at the same time, he was once again amazed at Yang Rui's level.

He doesn't know much about technology, but he is a person who knows how to do it. If one technical success is luck, it's hard to say the same thing the second time.

However, Director Hai didn't see anything after all, so he tentatively asked: "Professor Yu, what do you think if I say that a student made this technology?

"Has a student made it? Which school?

"I haven't verified it yet." Director Hai told a little lie, and then said: "Do you think it is possible for one person, a student, to solve this factory chemical synthesis route?

The other end of the phone was silent for ten seconds before Professor Yu's voice continued: "If you have the right equipment, instruments, systematic training, knowledge reserves, and luck, it's not a bad idea to do it alone. No. Students are also strong and weak. It’s not that they can’t do it, but it’s not easy...Let me say one more thing, if someone can complete this technology independently, whether it’s a student or a farmer, domestic research institutes should be able to open it up. door arrangement.

Director Hai thought about it, and said, "I understand. If the technology is proven to be true, are you interested in taking a look?"

Zeneca reduced its shareholding from 50% to 45%, not simply reducing it by 5%, but giving up its controlling stake. If Yang Rui cooperates with TCM Foreign Trade, it will be able to decide the direction of the new joint venture factory

Director Hai felt that if Yang Rui was brought into the system and entered a certain research institute, the control over the foreign trade of traditional Chinese medicine would be greatly enhanced

Director Hai had considered this idea as early as the time of the Westjet factory, and now it has only strengthened this idea

He felt that with the help of Professor Yu, whether it was the research institute or Yang Rui, he would be able to speak better.

Professor Yu was also curious about what he said, and said: "You have proved the technology. I must take a look. If possible, you can come to the University of Science and Technology of China to demonstrate it to our students and teachers. If it is not convenient, I will Take time out.

"We'll show you how to make you come here." Director Hai laughed, and the words were nice

Just like Shen Pinghui, the director of the Pingjiang Institute of Biotechnology, when necessary, will appear in front of the provincial leaders as the authority of the province's biology major. The road is not far behind, Professor Yu's reputation in the circle is also quite high

This kind of big cow-level person is of two levels from ordinary little professors, and Director Hai has to be careful.

After finishing the phone call with Professor Yu, Director Hai waited in peace for two days, and finally met Trapp, the chief representative of Zeneca who flew from the UK.

He brought four men this time, and more than ten kinds of instruments that can fit into a jeep. Trapp has learned how difficult it is to borrow instruments and equipment in China last time, and he does not want to experience it again this time.

Domestic research institutes, in many cases, do not directly use the equipment for people, but ask you to list the requirements, and then send special personnel to operate, for fear that any mistake will damage the equipment.

Trapp is not used to this kind of practice. When he came here this time, he simply loaded a truck full of instruments from Hong Kong and donated them to several universities in China when they were used up. This is also one of the various agreements Zeneca invested in China. .

Trapp sent the instrument to West Fort Middle School, and then worked with Yang Rui on the experiment of refining solanesol.

In terms of some key steps, Yang Rui still refused to disclose, but the number was less than last time. After all, he is also a person who has money to register patents now.

The experiment of refined solanesol went very smoothly, and Trapp gave a perfect evaluation, which gave Zeneca and TCM Foreign Trade great confidence.

Director Hai and Franky couldn't wait to sign the agreement with Yang Rui on the new joint venture factory.

Since Sinovel Pharmaceuticals is a Hong Kong company, the new joint venture factory has become a tripartite joint venture between China, Britain and Hong Kong, and the big names have taken off.

However, in order to minimize the trouble in choosing a crude solanesol factory, the three parties did not publicize the agreement to the outside world, but let Director Hai negotiate with various enterprises first.

Although TCM Foreign Trade also has its own technical department, they are mainly engaged in foreign trade. It is impossible to be proficient in technology, so Director Hai recruited Yang Rui to contact each company separately.

The production of solanesol by plant extraction method requires thousands of tons of raw materials even for crude solanesol, and to supply a refined solanesol factory, at least three or more crude solanesol factories are needed, five More than one is naturally better.

All these investments need to be invested by Sinopharm Foreign Trade. Of course, the profits generated by crude solanesol will also be shared by Sinopharm Foreign Trade and related enterprises.

Since it is the money earned by the foreign trade of traditional Chinese medicine, Director Hai has been extraordinarily attentive and has taken the trouble to conduct in-depth exchanges with various enterprises. Not only that, he also sent people to Yunnan and other major tobacco provinces to learn about the local tobacco production and sales.

Regarding Yang Rui, Chief Hai's attitude was extremely kind.

First of all, Yang Rui has won a certain political and economic status. It is a Sinovel pharmaceutical company. Although it is an empty shell like a leather bag company, it has many patents in it. ignore. These days, it's not that everyone can't imagine that registering a company in Hong Kong can be a Hong Kong-funded enterprise happily, but it's that everyone can't afford foreign exchange to do this kind of thing.

Secondly, Director Hai has become more and more aware of the difficulty of semi-synthetic production of coenzyme Q10. This is something that even the Beijing Institute of Biological Products cannot guarantee. Director Hai thinks it's amazing.

The third reason is that Director Hai really needs someone to help him judge the conditions for building a crude solanesol factory. In this regard, foreigners are untrustworthy, but his subordinates are of mediocre level, so Yang Rui has become the best choice.

Although he couldn't give Yang Rui a high salary, Director Hai did his best to serve Yang Rui as comfortably as possible, and the first thing he did was to move Yang Rui from the front building of Pingjiang Hotel to the back building.

At the same time, shrewd local enterprises seem to have noticed something.